Next-Gen minds at NRF-iThemba LABS: Bridging the gap from photons to protons in cancer research

At NRF-iThemba LABS, the Radiobiology laboratory is not only pushing the boundaries of cancer research but also nurturing the next generation of passionate scientists dedicated to making a meaningful difference. Meet Aobakwe Sekeleko (right) and Mmathapelo Mphelane (left), two remarkable young researchers whose dedication and curiosity inspire us all.

Aobakwe, a first-year MSc student in Applied Radiation Sciences from North-West University, describes his journey as an enriching experience that has deepened his understanding of how cells respond to radiation. For him, every experiment represents more than just data; it is a step towards understanding phenomena that could one day save lives. “The support and guidance I have received here have been invaluable,” he shares, emphasising the importance of teamwork and precision in this field.

Mphelane, a PhD candidate from Sefako Makgatho Health Sciences University, is passionately exploring the mechanisms of breast cancer. Her research investigates how cells repair DNA damage caused by ionising radiation, with the goal of advancing proton therapy techniques in the near future. Her main supervisor, Dr Peter Du Plessis, Radiobiologist, provides overarching guidance for her PhD work, while Dr Xanthene Muller, Biomedical Technician, her co-supervisor, also mentors Sekeleko in his MSc research. Their combined mentorship offers vital support to both young scientists.

According to Dr Du Plessis, the two will spend approximately two months at NRF-iThemba LABS at a time, after which they return to their respective universities for approximately two months before rotating back to the facility. This arrangement allows them to continue their postgraduate studies while gaining practical research experience at iThemba LABS. Sekeleko is expected to continue this arrangement until approximately mid-2027, while Mphelane will continue her rotations until the end of 2028.

Furthermore, they have both benefited from the insights and guidance of Dr Samantha Cairncross, who commenced her post-doctoral fellowship at NRF-iThemba LABS in June 2026 and is based within the Radiobiology research team. Her role has been supportive and collaborative, helping to deepen their understanding of the underlying biological processes and enrich their research experience. Her contributions complement the primary supervision, adding valuable perspectives to their development as researchers.

For Mphelane, each day presents a meaningful opportunity to contribute to a cause she cares deeply about. Both researchers are working in a laboratory environment that fosters purpose and hope. Their stories serve as a reminder that behind every scientific breakthrough are individuals committed to making a difference. Guided by experienced supervisors, Sekeleko and Mphelane exemplify the spirit of innovation that defines NRF-iThemba LABS.

As they continue their research, they carry with them the aspirations of improved cancer treatments and the hope of transforming lives. Their journey is a testament to the power of young minds dedicated to science and service.

NRF-iThemba LABS (Laboratory for Accelerator Based Sciences) is a multidisciplinary national research facility under the National Research Foundation (NRF), operating from sites in Cape Town and Johannesburg. It houses the only cyclotron facility on the African continent, with its separated-sector cyclotron ranking as the largest accelerator facility in the Southern Hemisphere. Beyond its work in nuclear and materials sciences, the facility conducts research and training in biomedical sciences and produces radioisotopes and radiopharmaceuticals for nuclear medicine, including applications in cancer diagnosis and treatment.