NRF Women's Month 2026: Dr Sheefa Mirza

Every research journey starts with a question. This Women’s Month, the NRF celebrates women driven by curiosity — researchers whose questions, ideas and determination are expanding our understanding of the world around us. From exploring the unknown to deepening our existing knowledge, curiosity remains at the heart of discovery. We thank all participants for sharing their stories with us.

Dr Sheefa Mirza is a Clinical Scientist in Precision Oncology at the University of the Witwatersrand. She holds an NRF Y-rating and is supported by an NRF Developmental Grant for Y-rated Researchers. Her research focuses on finding better ways to detect colorectal (bowel) cancer at an early stage.

How has your affiliation with the NRF impacted your studies/career?

I have been recognised by the National Research Foundation (NRF) with a Y-rating, acknowledging my potential as a “promising young researcher” with the capacity to become an established researcher within a few years. In addition, I received the NRF Developmental Grant for Y-rated Researchers, which provides dedicated funding to support the establishment of my independent research programme.

These recognitions have had a significant impact on my career by enabling me to establish an independent research programme focused on liquid biopsy approaches for early detection of cancer.

The developmental grant has allowed me to procure essential research consumables, establish new collaborations, and initiate key research activities. It has also strengthened my competitiveness for future external funding, enhanced my research profile, and contributed to building capacity for translational cancer research in South Africa.

What is your research focus or area of expertise?

My research focuses on finding better ways to detect colorectal (bowel) cancer at an early stage, when treatment is most effective. I study tiny particles called exosomes, which are naturally released by cells into the bloodstream and carry important genetic information.

By analysing these particles from a simple blood sample (known as a liquid biopsy), I aim to identify biomarkers that can help diagnose cancer earlier, monitor how patients respond to treatment, and improve patient outcomes.

My research also seeks to better understand why colorectal cancer is increasing in younger adults and to identify biological differences that could lead to more personalised approaches for diagnosis and treatment.

This work supports the growing field of precision oncology, where treatments and clinical decisions are tailored to the unique biological characteristics of each patient’s cancer rather than using a one-size-fits-all approach.

Ultimately, my goal is to develop less invasive, more accurate tests that enable earlier diagnosis, guide personalised treatment decisions, and improve cancer care and health outcomes in South Africa.

What sparked your curiosity about your field of research, and what continues to keep you curious?

My curiosity about cancer research began with a desire to understand why some cancers are diagnosed too late – when treatment options are limited, and outcomes are often poor. I became particularly interested in how advances in molecular biology could help detect cancer earlier and improve patient care. During my research career, I developed a strong interest in liquid biopsy and exosomes because they offer a minimally invasive way to gain valuable information about a tumour from a simple blood sample.

What continues to inspire me is the opportunity to translate laboratory discoveries into real clinical benefits. Every new biomarker discovered has the potential to improve early diagnosis, guide personalised treatment through precision oncology, and ultimately improve survival and quality of life for patients.

Working in South Africa also motivates me to address challenges that are particularly relevant to our population, including the rising incidence of colorectal cancer in younger adults and the need for accessible, cost-effective diagnostic tools.

What is one thing you wish more people understood about your field of research?

I wish more people understood that cancer research is not only about developing new treatments—it is also about finding better ways to prevent cancer, detect it earlier, and ensure that each patient receives the most effective care for their specific disease.

Small discoveries made in the laboratory, such as identifying a new biomarker, can eventually lead to major improvements in patient outcomes. Research in fields like liquid biopsy and precision oncology has the potential to make cancer diagnosis less invasive, more accurate, and more personalised, ultimately giving patients a better chance of successful treatment and a higher quality of life.

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